Smart Neurostimulation
for Brain Recovery & Health

From Vagus Nerve Activation
to Improved Brain Health

BODUS is based on auricular vagus nerve stimulation (aVNS), a non-invasive approach that targets sensory branches of the vagus nerve accessible through the external ear.

Electrical stimulation of vagally innervated auricular regions activates afferent pathways projecting to the nucleus tractus solitarius (NTS) and other brainstem networks involved in autonomic regulation, arousal and neuroplasticity. Through these pathways, aVNS can influence broader neural circuits associated with sleep, stress, mood and cardiovascular regulation.

BODUS uses a multisite stimulation strategy designed to engage different auricular vagal territories while maintaining a compact and comfortable form factor. 

By combining targeted neuromodulation, miniaturized electronics and connected digital monitoring, BODUS is designed to make aVNS precise, wearable and suitable for everyday use.

Stimulating the ear. Modulating the brain.

Illustration of auricular vagus nerve stimulation

Mechanism of action

Auricular stimulation

(ABVN)

Nucleus Tractus
Solitarius (NTS)

Neuromodulatory
networks (LC, etc.)

Autonomic modulation
& neuroplasticity

Scientific evidence driving innovation

Anatomical evidence

Auricular vagal targets

Neurophysiological evidence

Responses to auricular stimulation

Clinical evidence

Effects on brain function

Our research provides anatomical, neurophysiological and clinical evidence for the optimal stimulation of auricular vagal targets and their effects on brain function.

Selected XANA publications

Gurtubay I. et al.

2023

Publication details

Immediate effects and duration of a short and single application of transcutaneous auricular vagus nerve stimulation on P300 event-related potential.

Frontiers in Neuroscience, 17.

Gurtubay I.G. et al.

2021

Publication details

Evaluation of different vagus nerve stimulation anatomical targets in the ear by vagus evoked potential responses.

Brain and Behavior, 11(11).

Bermejo P. et al.

2017

Publication details

Innervation of the Human Cavum Conchae and Auditory Canal: Anatomical Basis for Transcutaneous Auricular Nerve Stimulation.

BioMed Research International, 2017.

Intellectual property

Patented miniaturized electronics

Patent portfolio

Títulos, números y enlaces pendientes de incorporar.